KEY TAKEAWAYS
- The study aimed to evaluate the impact of O6-MGMT activity on TMZ effectiveness in GBM treatment.
- The study provided evidence for using CRISPR-based gene suppression to overcome TMZ resistance and enhance its effectiveness in GBM.
Surgical resection followed by radiotherapy, along with concurrent and adjuvant chemotherapy using Temozolomide (TMZ), is the standard of care for patients with glioblastoma (GBM), the most prevalent and aggressive form of brain cancer. The efficacy of TMZ hinges on O6-methylguanine DNA methyltransferase (MGMT) activity, which repairs alkyl adducts at the DNA level, mitigating TMZ’s toxic effects.
Yasamin Yousefi and the team aimed to investigate strategies for enhancing the effectiveness of TMZ chemotherapy in GBM treatment, particularly by targeting O6-MGMT activity.
The study utilized fusions of catalytically-inactive Cas9 (dCas9) to DNA methyltransferases (dCas9-DNMT3A) to selectively downregulate MGMT transcription by inducing methylation at the MGMT promoter and K-M enhancer.
The results revealed a substantial decrease in MGMT expression, which correlates with increased sensitivity to TMZ in the HEK293T cell line.
The study provided evidence supporting the feasibility of using CRISPR-based gene suppression to overcome TMZ resistance and augment its cytotoxic effects in glioblastoma tumor cells.
No funding information was available.
Source: https://link.springer.com/article/10.1007/s11060-024-04708-0
Yousefi, Y., Nejati, R., Eslahi, A. et al. (2024). “Enhancing Temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT).” J Neurooncol (2024). https://doi.org/10.1007/s11060-024-04708-0
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- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
- PET Absence Post-TMZ Predicts Better Outcomes in HGG
KEY TAKEAWAYS The study aimed at amino-acid PET's prognostic value in HGG patients stopping TMZ…
