KEY TAKEAWAYS
- The study aimed to analyze 15-year trends in patients with DMM incidence and mortality.
- Researchers noticed that DMM’s incidence and incidence-based mortality rates have significantly increased in recent years.
Recent data show a significant increase in the detection and mortality rates of Desmoplastic Malignant Melanoma (DMM), highlighting the urgent need for comprehensive epidemiological analysis to inform precise medical and public health strategies.
Hai Yu and the team aimed to elucidate variations in DMM incidence and mortality over a 15-year period (2005-2019).
They performed an inclusive analysis utilizing data sourced from the Surveillance, Epidemiology, and End Results (SEER) database, specifically focusing on patients with DMM. Incidence and incidence-based mortality rates (IBM) were directly extracted from the SEER database. Joinpoint regression analysis was employed to analyze the data, enabling the calculation of the average annual percent change (AAPC) along with its corresponding 95% confidence interval (CI).
About 3,384 cases of DMM were identified between 2005 and 2019, boasting an age-adjusted incidence rate of 36.3 cases per 1000,000 person-years (95% CI 3.51-3.76) and an IBM of 1.65cases per 1000,000 person-years (95% CI 1.57-1.74). Of these, 2,353 were males (69.53%) and 1,031 were females (30.47%). There were 1894 patients (55.97%) who were over 70 years old. Predominantly, DMM lesions manifested in exposed areas: Limbs (955, 28.22%), Face (906, 26.77%), and Scalp and Neck (865, 25.56%).
The incidence of DMM increased significantly at a rate of APC = 0.9% during 2005-2019, while the incidence-based mortality showed a significant upward trend (APC = 7%) during 2005-2012, and slowly increasing trend (APC = 0.6%) during 2012-2019. In contrast to the modest upward trajectory in female incidence and mortality, male incidence initially surged, later declining, while male mortality peaked and stabilized post-2012. The primary sites for incidence and mortality were chronically sun-exposed areas: Face, Scalp and Neck, and Limbs.
In recent years, there has been a notable rise in both the incidence and incidence-based mortality rates of DMM. Subgroup analyses revealed distinct trends within different demographic groups, underscoring the importance of tailored approaches in understanding and addressing the complexities of DMM.
The study was funded by the Key Scientific Problems and Medical Technical Problems Research Project of China Medical Education Association and Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization.
Source: https://pubmed.ncbi.nlm.nih.gov/38796649/
Yu H, Zhu L, Zhang J, et al. (2024). “Joinpoint regression analysis of recent trends in desmoplastic malignant melanoma incidence and mortality: 15-year multicentre retrospective study.” Arch Dermatol Res. 2024 May 25;316(6):273. doi: 10.1007/s00403-024-02928-y. PMID: 38796649.
