KEY TAKEAWAYS
- The study aimed to explore factors impacting short-term survival after complete resection in patients with IDH1 wild-type glioblastoma.
- The study found unexpected short-term survival after glioblastoma resection, with early non-local recurrence and no significant genetic alterations.
Mariko Toyoda and the team aimed to delve into factors impacting short-term survivors after complete resection in patients with IDH1 wild-type primary glioblastoma, a type of brain cancer.
The study analyzed 5 independent cohorts of patients who underwent gross total resection, comprising 83 participants from 1 cohort and additional cohorts totaling 363 patients. Short-term survivors were defined as those with an overall survival of 12 months or less after resection, followed by radiation therapy and concurrent and adjuvant temozolomide.
The results revealed that among the 446 patients with glioblastoma included in the study, all cohorts experienced unexpected short-term survival after gross total resection, ranging from 15.0% to 23.9% of cases. Molecular profiling showed no significant difference in major genetic alterations between the short-term survival and non-short-term survival groups, including MGMT, TERT, EGFR, PTEN, and CDKN2A.
Clinically, the short-term survival group exhibited a higher incidence of non-local recurrence early in their treatment course, with 60.0% in the initial cohort and 43.5% in the validation cohort.
The study’s findings suggested that unexpected short-term survival after gross total resection in glioblastoma patients is frequent, often accompanied by early non-local recurrence.
No significant genetic alterations were detected in the short-term survival group, indicating that such alterations are inherent characteristics of glioblastoma rather than reliable predictors for recurrence patterns or the development of unexpected short-term survival.
Research received partial support from various sources, including the Japan Society for the Promotion of Science (JSPS) KAKENHI, a Research Grant for young medical doctors and healthcare professionals from SRL, and several other foundations and organizations.
Source: https://link.springer.com/article/10.1007/s11060-024-04687-2
Toyoda, M., Shibahara, I., Shigeeda, R., et al. (2024). “Clinical and molecular features of patients with IDH1 wild-type primary glioblastoma presenting unexpected short-term survival after gross total resection.” J Neurooncol (2024). https://doi.org/10.1007/s11060-024-04687-2
