KEY TAKEAWAYS
- The study aimed to examine ccRCC’s vascularization, immune infiltration, TME roles in disease progression, and treatment outcomes.
- The results revealed RNA sequencing data is crucial for advancing validation studies and personalized ccRCC therapy.
Clear cell renal cell carcinoma (ccRCC), the prevalent renal cancer in adults, emerges as a highly vascularized and immune-infiltrated solid tumor. The excessive production of vascular endothelial growth factor A fosters unregulated vessel growth and immunosuppression. The tumor microenvironment (TME) significantly influences disease progression, drug targeting, response, and patient outcomes.
Elin Sjöberg and the team aimed to investigate how ccRCC progresses, responds to drugs, and impacts patient outcomes through tumor microenvironment analysis.
The study reviewed experimental models, large-scale omics approaches, and patient prognosis and therapy prediction techniques to understand the endothelium in ccRCC and its interaction with the surrounding TME.
The results revealed that preclinical and clinical studies have unveiled molecular mechanisms of endothelial cross-talk pertinent to disease progression, patient prognosis, and therapy prediction. Despite this, there is a scarcity of representative ccRCC experimental models. Omics approaches have delineated clinically relevant subsets of angiogenic and immune-infiltrated tumors, highlighting distinct molecular signatures and discrete populations of endothelial and immune cells in patients.
The study concluded that recent genetically engineered ccRCC mouse models, along with emerging evidence from single-cell RNA sequencing data, offer opportunities for future validation studies.
These studies, including multiplex imaging of ccRCC patient cohorts, hold significance for enhancing therapy benefits and facilitating personalized treatment approaches for patients with ccRCC.
No funding information was available.
Source: https://pubmed.ncbi.nlm.nih.gov/38863726/
Sjöberg E. (2024). “Molecular mechanisms and clinical relevance of endothelial cell cross-talk in clear cell renal cell carcinoma.” Ups J Med Sci. 2024 May 8;129. doi: 10.48101/ujms.v129.10632. PMID: 38863726; PMCID: PMC11165252.
