[Comment] Initially unresectable colorectal liver metastases: the best therapeutic regimens

Despite the advances in systemic chemotherapy and molecular targeted therapy, local treatment, including resection and local ablative treatment, is the only treatment of choice that can provide prolonged survival in patients with colorectal liver metastases. Therefore, for initially unresectable colorectal liver metastases, a sufficient response to optimal systemic chemotherapy with biological targeted drugs to allow subsequent surgical treatment would be an important development and could lead to improvemnts in long-term survival.