CASC21 SNPs Linked to Increased Cervical Cancer Risk

CASC21 is identified as a significant gene in cervical cancer. However, its genetic variations’ impact on cervical cancer remains unexplored despite genetic influences on its occurrence.

Lili Han and the team conducted a study that aimed to investigate the association between CASC21 genetic variations and cervical cancer.

About 973 individuals, comprising 494 cervical cancer patients and 479 healthy controls, participated. The Agena MassARRAY platform genotyped 5 single nucleotide polymorphisms (SNPs) in the CASC21 gene. Data analysis involved a Chi-squared test, logistic regression analysis, odds ratio (OR), multifactor dimensionality reduction (MDR), and 95% confidence interval (95%CI).

In the comprehensive analysis, both rs16902094 (P= .014, OR = 1.86, 95% CI = 1.12-3.08) and rs16902104 (P= .014, OR = 1.86, 95% CI = 1.12-3.09) exhibited a significant association with an increased risk of cervical cancer.

The stratified analysis results showed that these correlations persisted in subgroups with cervical squamous cell carcinoma, age higher than 51, BMI less than 24 kg/m², and smoking status. Moreover, MDR analysis found that rs16902094 (which contributes 0.49%) and rs16902104 (which contributes 0.52%) were the main factors impacting the risk of cervical cancer.

The study concluded that the correlation between two CASC21 SNPs (rs16902094, rs16902104) and increased cervical cancer risk aids knowledge of CASC21’s function in cervical carcinogenesis. Funding was provided by the National natural science foundation of China.

Source: https://pubmed.ncbi.nlm.nih.gov/38465665/

Han L, Liu J, Shataer M, et al. (2024). “The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer,” Cancer Biology & Therapy, 25:1, DOI: 10.1080/15384047.2024.2322207.