KEY TAKEAWAYS
- The study aimed to investigate the relationship between ALI and the prognosis of stroke patients.
- Researchers noticed a reverse J-shaped non-linear link between ALI and all-cause mortality, underscoring the need to control ALI within a suitable range for better stroke prognosis.
Stroke was a major global public health challenge, and its prognosis was remarkably associated with inflammation levels and nutritional status. The advanced lung cancer inflammation index (ALI) was a comprehensive indicator that combined inflammation and nutritional status. The relationship between ALI and the prognosis of stroke patients was not yet known.
Xiaokun Chen and the team aimed to assess the utility of ALI in predicting outcomes for stroke patients.
They performed an inclusive analysis utilizing cohort data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The association between ALI and all-cause and cardiovascular disease (CVD) mortality in stroke patients was estimated using a multivariable adjusted Cox model. Their non-linear relationship was analyzed by restricted cubic spline analysis. Sensitivity analysis was constructed through stratified analysis and interaction analysis.
About 1,440 stroke patients were included in this study. An elevated ALI was significantly related to a reduced risk of all-cause mortality in stroke patients but not related to CVD mortality. A reverse J-shaped non-linear association between ALI and all-cause mortality in stroke patients, with an inflection point at 83.76 (the lowest of the mortality risk). On the left side of the inflection point, for each 10 U increase in ALI, there was a 16% reduction in the risk of all-cause mortality. However, on the right side, the risk increased by 6%. There was no remarkable interaction between stratified variables and ALI.
The study concluded that elevated ALI was closely associated with a reduced risk of all-cause mortality in stroke patients, indicating a potential prognostic significance. The observed reverse J-shaped non-linear relationship existed between the 2, with an inflection point at 83.76, emphasizing the importance of maintaining ALI within an appropriate range for improved prognosis.
These findings suggest the necessity of interventions such as weight management, albumin supplementation, and anti-inflammatory treatment to control ALI in stroke patients. Furthermore, the dynamic variation in ALI offers a promising avenue for clinicians to establish personalized criteria, potentially enhancing long-term survival outcomes for stroke patients.
This study was sponsored by the Quanzhou Science and Technology Bureau, Quanzhou, China, the Natural Science Foundation of Fujian Province, and Joint funds for the innovation of science and technology, Fujian province.
Source: https://pubmed.ncbi.nlm.nih.gov/38699426/
Chen X, Hong C, Guo Z, et al (2024). “Association between advanced lung cancer inflammation index and all-cause and cardiovascular mortality among stroke patients: NHANES, 1999-2018.” Front Public Health. 2024 Apr 18;12:1370322. doi: 10.3389/fpubh.2024.1370322. PMID: 38699426; PMCID: PMC11063327.
