KEY TAKEAWAYS
- The study aimed to investigate the causal association between psoriasis and bladder cancer using bidirectional two-sample MR analysis.
- Researchers noticed no evidence connecting psoriasis to bladder cancer.
Previous epidemiological observational studies have revealed a possible association between psoriasis and bladder cancer, but the results have been inconsistent, making causality questionable.
Lihuan Du and the team conducted a bidirectional two-sample Mendelian randomization (MR) analysis to determine whether there are causal connections between psoriasis and bladder cancer.
Researchers performed a two-sample MR analysis using publicly accessible genome-wide association study (GWAS) data for individuals with psoriasis and bladder cancer. The primary method employed was the inverse variance weighted (IVW) method, supplemented by complementary approaches including the weighted median, MR-Egger, weighted mode, and simple mode methods.
Detection of heterogeneity and pleiotropy in the MR results was undertaken. Additionally, leave-one-out sensitivity analysis was employed to assess the robustness and validity of the findings.
In terms of causative associations, the IVW technique (OR = 0.999, 95% CI 0.977-1.022; P = 0.956) revealed no significant relationship between psoriasis occurrence and bladder cancer risk. The IVW method revealed no causal relationship between bladder cancer and psoriasis risk (OR = 0.979, 95% CI 0.873-1.098; P = 0.716).
Consistency was found in the results of complementary methods. Horizontal pleiotropy or heterogeneity (P > 0.05) was not notable in the MR analysis. Sensitivity analysis confirmed that MR estimates were not influenced by single-nucleotide polymorphisms (SNPs).
The study determined that there is no evidence that psoriasis causes bladder cancer.
The study was sponsored by the Natural Science Foundation of Zhejiang Province & National Natural Science Foundation of China.
Source: https://pubmed.ncbi.nlm.nih.gov/38533746/
Du L, Wang B, Wen J, et al. (2024). “Examining the causal association between psoriasis and bladder cancer: A two-sample Mendelian randomization analysis.” Skin Res Technol. 2024 Apr;30(4):e13663. doi: 10.1111/srt.13663. PMID: 38533746; PMCID: PMC10966512.
