KEY TAKEAWAYS
- The study aimed to investigate the relationship between insulin use, social determinants, covariates, and non-melanoma skin cancer risk in diabetic individuals.
- The study concluded that variances in insulin usage and NMSC development are associated with socioeconomic disparities and behavioral tendencies.
Non-melanoma skin cancer (NMSC) is a common malignancy with a rising global incidence. While linked to diabetes, insulin’s impact on NMSC risk amidst social determinants remains unexplored.
Nour Massouh and the team aimed to explore how insulin use, social determinants of health (SDOH), and additional covariates interact with NMSC risk in diabetic individuals.
The study utilized the 2020 Behavioral Risk Factor Surveillance System (BRFSS), an annual national survey in the US. The analysis included weighted chi-squared tests, logistic regression, and survival analyses on 8685 eligible BRFSS participants with diabetes.
The results revealed that Kaplan Meier survival curves depicted a higher probability of NMSC event-free survival for participants with diabetes using insulin compared to those not using insulin (log-rank test P< .001). Significant associations were detected between insulin use and [reduced odds of NMSC (OR .56; 95% CI: .38-.82), also decreased (HR .36; 95% CI: .21-.62), alongside indices of SDOH.
The study concluded that variances in insulin usage and the occurrence of NMSC are associated with socioeconomic disparities and behavioral patterns.
Source: https://pubmed.ncbi.nlm.nih.gov/38680117/
Massouh N, Jaffa AA, Jaffa MA. (2024). “Role of Insulin Use and Social Determinants of Health on Non-melanoma Skin Cancer: Results From the Behavioral Risk Factor Surveillance System.” Cancer Control. 2024 Jan-Dec;31:10732748241249896. doi: 10.1177/10732748241249896. PMID: 38680117.
