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A phase 3, RATIONALE-306 study that was global, randomized, double-blind, parallel-arm, and placebo-controlled was carried out at 162 medical centers in Asia, Europe, Oceania, and North America. The present study provides interim analysis outcomes from the RATIONALE-306 trial, which aimed to evaluate the efficacy of tislelizumab. Tislelizumab, an anti-PD-1 antibody, has demonstrated antineoplastic […]...
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Background Bispecific T-cell engagers (BTEs) are novel agents used to treat hematological malignancies. Early trials were underpowered to define cardiovascular adverse events (CVAE) and no large-scale studies systematically examined the CVAEs associated with BTEs. Methods Leveraging the US …
Background The combination of immune-checkpoint inhibitors and antiangiogenic agents can synergistically modulate the tumor microenvironment and represents a promising treatment option. Here, we evaluated the efficacy and safety of camrelizumab plus famitinib (a receptor tyrosine kinase …
With the global incidence of non-small cell lung cancer (NSCLC) on the rise, the development of innovative treatment strategies is increasingly vital. This review underscores the pivotal role of precision medicine in transforming NSCLC management, …
Introduction: Spinal metastases are common in metastatic cancer, affecting around 40% of patients. The primary treatment involves radiation therapy, transitioning from conventional external beam radiation therapy (EBRT) to stereotactic body radiation therapy (SBRT) for its …
