Relevant Articles About Research and Clinical Trials in Gastrointestinal Cancer
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KEY TAKEAWAYS The study aimed to examine the direct effects of combining nintedanib with anti-angiogenic agents on UM cell behavior. The results showed that nintedanib suppresses UM cell growth; further research is needed to explore therapeutic potential in UM....
KEY TAKEAWAYS The study aimed to investigate the spatial relationships between tumor-infiltrating leukocytes and lymphovasculature in primary human cutaneous melanoma. The study presented a platform mapping lymphovascular and immune infiltrates in primary melanoma,...
KEY TAKEAWAYS The study aimed to investigate the incidence of HH and its impact on outcomes following esophagectomy in esophageal adenocarcinoma patients. Researchers noticed that, despite higher postoperative complications in HH patients, low positive margin rates...
The EMERALD-1, phase 3 trial, aimed to investigate the efficacy of TACE with D and B in pts with uHCC. The primary endpoint …
A phase 3, RATIONALE-306 study that was global, randomized, double-blind, parallel-arm, and placebo-controlled was carried out at 162 medical centers in Asia, Europe, …
The phase 3 clinical trial KEYNOTE-590 evaluated the efficacy and cost-effectiveness of Pembrolizumab in combination with chemotherapy as the initial treatment regimen for …
Background Bispecific T-cell engagers (BTEs) are novel agents used to treat hematological malignancies. Early trials were underpowered to define cardiovascular adverse events (CVAE) and no large-scale studies systematically examined the CVAEs associated with BTEs. Methods Leveraging the US …
Background The combination of immune-checkpoint inhibitors and antiangiogenic agents can synergistically modulate the tumor microenvironment and represents a promising treatment option. Here, we evaluated the efficacy and safety of camrelizumab plus famitinib (a receptor tyrosine kinase …
With the global incidence of non-small cell lung cancer (NSCLC) on the rise, the development of innovative treatment strategies is increasingly vital. This review underscores the pivotal role of precision medicine in transforming NSCLC management, …
Introduction: Spinal metastases are common in metastatic cancer, affecting around 40% of patients. The primary treatment involves radiation therapy, transitioning from conventional external beam radiation therapy (EBRT) to stereotactic body radiation therapy (SBRT) for its …